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雑誌文献

臨床検査54巻3号

2010年03月発行

文献概要

今月の主題 骨髄増殖性疾患 話題

骨髄増殖性疾患と血栓・止血

著者: 横山健次1

所属機関: 1慶應義塾大学医学部血液内科

ページ範囲:P.304 - P.308

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1.はじめに

 骨髄増殖性疾患(myeloproliferative disorder;MPD)では血栓症の発症頻度が高くなることが報告されている.一方で皮下出血などの出血症状もしばしばみられる症状である.なかでも真性多血症(polycythemia vera;PV),本態性血小板血症(essential thrombocythemia;ET)では血栓症は主要な死因であり,予後を左右する.本稿ではPV,ET患者を中心に,血栓症,出血症状の頻度,成因,治療法などに関して解説する.

参考文献

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14) Carobbio A, Finazzi G, Antonioli E, et al:Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia. Blood 112:3135-3137, 2008
15) Carobbio A, Antonioli E, Guglielmelli P, et al:Leukocytosis and risk stratification assessment in essential thrombocythemia. J Clin Oncol 26:2732-2736, 2008
16) Barbui T, Carobbio A, Rambaldi A, et al:Perspectives on thrombosis in essential thrombocythemia and polycythemia vera:is leukocytosis a causative factor? Blood 114:759-763, 2009
17) Harrison CN, Campbell PJ, Buck G, et al:Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med 353:33-45, 2005
18) Santilli F, Romano M, Recchiuti A, et al:Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients. Blood 112:1085-1090, 2008
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20) Landolfi R, Di Gennaro L:Prevention of thrombosis in polycythemia vera and essential thrombocythemia. Haematologica 93:331-335, 2008

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

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