臨床検査54巻6号

2010年06月発行

今月の主題 注目されるサイトカイン 各論

IL-12サイトカインファミリー

著者： 吉田裕樹¹

所属機関： ¹佐賀大学医学部分子生命科学講座

ページ範囲：P.599 - P.605

　IL-12関連サイトカイン，IL-27, 23は抗原提示細胞から産生され，Th1細胞の分化・維持を制御する．さらに，IL-23は炎症誘導作用をもつTh17の分化を促進する．一方，IL-27には，IL-23と逆にTh17の分化を抑制するほか，様々なサイトカイン産生を抑制し，炎症を抑制する作用をもつ．IL-27に類似した作用をもつIL-35は，制御性T細胞から産生され，その免疫抑制作用の一部を担う．IL-12サイトカインファミリーは，ヘルパーT細胞の分化や機能を微細に制御している．

参考文献

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