臨床検査54巻6号

2010年06月発行

今月の主題 注目されるサイトカイン 各論

抗炎症性サイトカインIL-10とIL-35

著者： 溝口出¹ 森嶋紀子¹ 奥村昌恵¹ 千葉祐規乃¹ 善本隆之¹

所属機関： ¹東京医科大学難病治療研究センター

ページ範囲：P.607 - P.613

　interleukin(IL)-10は，免疫寛容の誘導・維持や過剰な免疫反応の制御に重要な抑制性サイトカインであり，病原体排除や自己免疫性反応におけるエフェクターT細胞による過剰な炎症反応の制御や，腸内細菌と腸管免疫系との共生によって保たれている腸内環境の恒常性の維持に関与している．IL-10の産生は，内在性Foxp3^＋制御性T(Treg)細胞や誘導性Treg(iTreg)，IL-10を産生するタイプ1型のTreg(Tr1)細胞，Th1細胞，Th2細胞，Th17細胞など種々の細胞で見られる．IL-35は，一番新しいサイトカインで，Treg細胞から産生され，IL-10やtransforming growth factor(TGF)-βと同様にTreg細胞の免疫抑制活性を担っているサイトカインの一つである．

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