臨床検査54巻6号

2010年06月発行

今月の主題 注目されるサイトカイン 各論

アレルギーとサイトカイン

著者： 浅井友香里¹ 北島裕子¹ 井上博雅¹

所属機関： ¹九州大学大学院医学研究院呼吸器内科学

ページ範囲：P.630 - P.635

　アレルギー性炎症の病態には，IL-4，IL-5，IL-9，IL-13などのTh2(T helper 2)タイプのサイトカインが重要な役割を担っている．これらのサイトカインは，細胞膜上の受容体に結合し受容体が活性化すると，JAK/STAT系，Ras/ERK系などのシグナルが働くことにより応答遺伝子発現を変化させ作用が発現し，サイトカインシグナル抑制因子の発現も変化させる．最近，これら従来からのTh2サイトカインに加え，アレルギー性炎症におけるIL-18，新規Th2サイトカインIL-25，新規Th2関連サイトカインIL-33などの役割が注目されている．

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