臨床検査55巻11号

2011年10月発行

特集 ここまでわかった自己免疫疾患 各論 3．膠原病と類縁疾患

9) 抗リン脂質抗体症候群

著者： 渥美達也¹

所属機関： ¹北海道大学大学院医学研究科内科学講座第二内科

ページ範囲：P.1193 - P.1199

抗リン脂質抗体症候群(APS)は，自己免疫血栓症あるいは妊娠合併症である．APS患者の半数は全身性エリテマトーデス(SLE)に合併し，APSを定義する抗リン脂質抗体はSLEの分類基準の項目にも採択されていて，APSはSLEの類縁疾患である．本邦でのAPSの診断には，凝固検査であるループスアンチコアグラントと免疫検査である(β2-グリコプロテインⅠ依存性)抗カルジオリピン抗体が用いられている．近年は抗β2-グリコプロテインⅠ抗体や，ホスファチジルセリン依存性抗プロトロンビン抗体も本邦の臨床検査に導入されつつある．

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