臨床検査55巻11号

2011年10月発行

特集 ここまでわかった自己免疫疾患 各論 4．そのほかの自己免疫疾患

7) Guillain-Barré症候群

著者： 駒ヶ嶺朋子¹ 結城伸𣳾²

所属機関： ¹獨協医科大学神経内科 ²シンガポール国立大学微生物学・内科学

ページ範囲：P.1249 - P.1257

C. jejuni(Campylobacter jejuni)腸炎後に発症する軸索型Guillain-Barré症候群は，分子相同性による抗体産生機序が立証された最初の自己免疫疾患である．患者から分離されたC. jejuniのリポオリゴ糖はヒト神経組織に存在するGM1ガングリオシドと糖鎖相同性を有していた．ヒト組織に類似した構造をもつ病原体に感染することにより病原抗体である抗ガングリオシド抗体が誘導され，神経組織の傷害が起こり弛緩性四肢麻痺に至る．抗ガングリオシド抗体の病的意義の確立は，抗体の種類によるGuillain-Barré症候群とその類縁疾患の分類再編を支持する．

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