臨床検査55巻4号

2011年04月発行

今月の主題 静脈血栓塞栓症と凝固制御因子プロテインS 各論

Protein S-Tokushima(K155E)

著者： 林辰弥¹ 鈴木宏治²

所属機関： ¹三重県立看護大学生化学 ²三重大学

ページ範囲：P.373 - P.377

protein S-Tokushima(K155E)は，タイプⅡプロテインS欠損症の女性の血漿中に見いだされたプロテインS分子の155番目(プロテインS前駆体では196番目)のリジンがグルタミン酸に変化した分子異常プロテインS分子であり，活性化プロテインC(APC)コファクター活性が著しく低下している．これまでのところ，protein S-Tokushimaは欧米人ではみられないことから，アジア人種，特に日本人に特有の変異であり，日本人における静脈血栓症の危険因子であることが示唆されている．

参考文献

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