臨床検査55巻6号

2011年06月発行

今月の主題 脂肪細胞 各論

脂肪細胞とホルモン

著者： 高橋和広¹

所属機関： ¹東北大学大学院医学系研究科保健学専攻基礎検査医科学講座内分泌応用医科学分野

ページ範囲：P.555 - P.560

脂肪細胞は，レプチンの発見以来，様々なペプチドホルモンやサイトカインなど生理活性物質を産生・分泌する内分泌細胞であると考えられるようになってきた．脂肪細胞から分泌される生理活性物質はアディポカイン(アディポサイトカイン)と総称されるが，食欲・代謝・循環・生殖など，様々な生理機能の調節に，中枢性および末梢性に重要な作用を担っており，代謝症候群・糖尿病・高血圧などの病態に関与している事実が明らかになってきた．本稿では，アディポカインのうち，ペプチドホルモンに焦点をしぼり概説したい．

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