臨床検査56巻2号

2012年02月発行

今月の主題 生理活性脂質 総論

第二世代の生理活性脂質リゾリン脂質

著者： 板井恵理子¹ 近藤朋恵¹ 首藤啓明¹ 橋本崇史¹ 青木淳賢¹

所属機関： ¹東北大学大学院薬学研究科分子細胞生化学分野

ページ範囲：P.125 - P.136

脂質は生体膜の成分として重要なだけでなく，ある種の状況において膜脂質より産生され，生理活性脂質として機能する．このような脂質は“脂質メディエーター”として知られている．ステロイドホルモンやアラキドン酸代謝物であるエイコサノイドに代表されるような第1世代の脂質メディエーターに加え，近年，単なる脂質代謝中間代謝物としてしか考えられていなかったリゾリン脂質が，第2世代の脂質メディエーターとして注目を浴びている．ゲノムに直接コードされていない脂質メディエーターは，どのように産生され，どのような機能を果たすのだろうか．本稿では，代表的なリゾリン脂質であるリゾホスファチジン酸，スフィンゴシン-1-リン酸，リゾホスファチジルセリンの生理作用を，その産生酵素や受容体と絡めて，最新のトピックスとともに紹介する．

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