臨床検査56巻5号

2012年05月発行

今月の主題 成長と臨床検査値 各論

黄疸とビリルビン異常の検査

著者： 伊藤進¹ 國方淳¹

所属機関： ¹香川大学医学部小児科

ページ範囲：P.497 - P.502

ビリルビンの化学構造は，非対称性のtetrapyrroleで，C-8とC-18に2つcarboxyethyl基をもつ2つのdipyrroleからなり，Δ⁴とΔ¹⁵でZ配座をとり，2つのdipyrroleは，中心部で97°で本を開いた立体構造である．ビリルビンは，疎水性のためヒト血清アルブミンと可逆的に結合して，種々の組織の生体膜に分布している．ビリルビン代謝は，生成，分布，肝での取り込み，抱合，排泄，腸肝循環，光異性化および酸化からなる．現在，高速液体クロマトグラフィ法による血清ビリルビン分析がゴールドスタンダードである．

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