臨床検査57巻4号

2013年04月発行

今月の特集2 非アルコール性脂肪性肝疾患

鉄代謝からみた病態のメカニズム

著者： 宮西浩嗣¹ 加藤淳二¹

所属機関： ¹札幌医科大学医学部内科学第四講座

ページ範囲：P.432 - P.437

■H₂O₂とFe^2＋の作用でOH^－＋・OH＋Fe^3＋が生成されるFenton反応では，最も毒性の強い活性酸素種（ROS）であるhydroxyl radical（・OH）が多量に生じる．

■過剰鉄は酸化ストレスを誘引するsecond hit因子の1つであることが想定されている．

■血清フェリチンが非アルコール性脂肪性肝疾患（NAFLD）の組織学的重症度・線維化の予測因子となる可能性が大規模臨床研究により示されている．

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