臨床検査57巻7号

2013年07月発行

今月の特集2 感染症と発癌

肝炎ウイルスと肝癌

著者： 小池和彦¹

所属機関： ¹東京大学大学院医学系研究科消化器内科学

ページ範囲：P.746 - P.753

■C型慢性肝炎やB型慢性肝炎においては，高頻度かつ多中心性の肝癌が発生する．

■ウイルス肝炎における肝発癌にかかわる因子として，免疫を介した炎症とウイルス自体などがある．

■B型肝炎における肝発癌においては，ウイルス量に代表されるウイルス因子が重要である．

■B型肝炎ウイルスのHBx蛋白やC型肝炎ウイルスのコア蛋白は，発癌への関与が実験的に示されてきている．

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