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雑誌詳細

文献概要

今月の特集2 深在性真菌症を学ぶ

Pneumocystis jirovecii

著者: 藤井毅1

所属機関: 1東京医科大学八王子医療センター 感染症科

ページ範囲:P.117 - P.121

●ニューモシスチス肺炎(PCP)は基本的に重篤な疾患であり,救命のためには早期診断および早期治療が極めて重要である.

●ほかの真菌と異なり培養されないため,確定診断は気道由来検体の直接鏡検によって菌体を証明する必要がある.臨床症状や画像所見,血中β-D-グルカン値,PCR法などの遺伝子検査の結果から,総合的に診断されることも少なくない.

●Pneumocystis jiroveciiは,ヒト-ヒト感染することが証明されており,免疫不全患者における院内伝播にも十分な注意が必要である.

参考文献

1)Stringer JR, Beard CB, Miller RF, et al:A new name (Pneumocystis jiroveci) for Pneumocystis from humans. Emerg Infect Dis 8:891-896,2002
2)Ng VL, Yajko DM, Hadley WK:Extrapulmonary pneumocystosis. Clin Microbiol Rev 10:401-418,1997
3)Tanaka M, Sakai R, Koike R, et al:Pneumocystis jirovecii pneumonia associated with etanercept treatment in patients with rheumatoid arthritis: a retrospective review of 15 cases and analysis of risk factors. Mod Rheumatol 22:849-858,2012
4)Vargas SL, Hughes WT, Santolaya ME, et al:Search for primary infection by Pneumocystis carinii in a cohort of normal, healthy infants. Clin Infect Dis 32:855-861,2001
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7)Mori S, Cho I, Ichiyasu H, et al:Asymptomatic carriage of Pneumocystis jiroveci in elderly patients with rheumatoid arthritis in Japan : a possible association between colonization and development of Pneumocystis jiroveci pneumonia during low-dose MTX therapy. Mod Rheumatol 18:240-246,2008
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14)Koga M, Koibuchi T, Kikuchi T, et al:Kinetics of serum β-D-glucan after Pneumocystis pneumonia treatment in patients with AIDS. Intern Med 50:1397-1401,2011
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20)Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents (http://aidsinfo.nih.gov/guidelines)
21)Tasaka S, Tokuda H:Pneumocystis jirovecii pneumonia in non-HIV-infected patients in the era of novel immunosuppressive therapies. J Infect Chemother 18:793-806,2012

掲載雑誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

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