臨床検査58巻8号

2014年08月発行

今月の特集2 血栓症時代の検査

血栓症の分子病態と臨床検査

著者： 鈴木宏治¹

所属機関： ¹鈴鹿医療科学大学　薬学部

ページ範囲：P.940 - P.948

●血栓症は血管内での病的血栓の形成により起こり，その背景には先天性ならびに後天性血栓性素因がある．

●病的血栓形成の原因には，①血流の異常，②血管内皮の異常，③血液成分の異常が考えられている（Virchow’s triad）．

参考文献

1）Brotman DJ, Deitcher SR, Lip GY, et al：Virchow’s triad revisited. South Med J　97：213-214，2004

2）Prandoni P：Links between arterial and venous disease. J Intern Med　262：341-350，2007

3）Fox EA, Kahn SR：The relationship between inflammation and venous thrombosis. A systematic review of clinical studies. Thromb Haemost　94：362-365，2005

4）Iwata H, Kaibara M, Dohmae N, et al：Purification, identification, and characterization of elastase on erythrocyte membrane as factor IX-activating enzyme. Biochem Biophys Res Commun　316：65-70，2004

5）Hayashi T, Honda G, Suzuki K：An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells. Blood　79：2930-2936，1992

6）Prandoni P, Bilora F, Marchiori A, et al：An association between atherosclerosis and venous thrombosis. N Engl J Med　348：1435-1441，2003

7）Morrissey JH, Choi SH, Smith SA：Polyphosphate: an ancient molecule that links platelets, coagulation, and inflammation. Blood　119：5972-5979，2012

8）Miyawaki Y, Suzuki A, Fujita J, et al：Thrombosis from a prothrombin mutation conveying antithrombin resistance. N Engl J Med　366：2390-2396，2012

9）松田道生，諏合輝子　中三川千鶴子，他：遺伝性異常フィブリノゲン血症．日血栓止血会誌　12：47-56，2001

10）Kamada H, Hattori K, Hayashi T, et al：In vitro evaluation of blood coagulation activation and microthrombus formation by a microchannel array flow analyzer. Thromb Res　114：195-203，2004

11）Kamada H, Okamoto T, Hayashi T, et al：An in vitro method for screening anti-platelet agents using a microchannel array flow analyzer. Biorheology　47：153-161，2010

12）Kikuchi Y：Effect of leukocytes and platelets on blood flow through a parallel array of microchannels: micro- and macroflow relation and rheological measures of leukocyte and platelet activities. Microvasc Res　50：288-300，1995

13）Yamamoto J, Inoue N, Otsui K, et al：Global Thrombosis Test (GTT) can detect major determinants of haemostasis including platelet reactivity, endogenous fibrinolytic and thrombin generating potential. Thromb Res　133：919-926，2014

14）Hosokawa K, Ohnishi T, Kondo T, et al：A novel automated microchip flow-chamber system to quantitatively evaluate thrombus formation and antithrombotic agents under blood flow conditions. J Thromb Haemost　9：2029-2037，2011

15）Hosokawa K, Ohnishi T, Sameshima H, et al：Comparative evaluation of direct thrombin and factor Ⅹa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model. PLoS ONE　9：e86491，2014