臨床検査58巻8号

2014年08月発行

今月の特集2 血栓症時代の検査

血栓性素因の検査医学的アプローチ

著者： 阪田敏幸¹²

所属機関： ¹国立循環器病センター研究所　分子病態部 ²アイ・エル・ジャパン

ページ範囲：P.949 - P.954

●日本人における静脈血栓塞栓症（VTE）の主な血栓性素因は，アンチトロンビン（AT），プロテインC（PC），およびプロテインS（PS）欠損症である．

●スクリーニングに用いる測定法はそれぞれの因子によって異なるため，対象ごとに適切な測定法を選択する必要がある．

●PCあるいはPS欠損症のスクリーニングには，PCの抗凝固活性とPS活性測定がそれぞれ重要である．

●フェノタイプおよびサブタイプの同定は，AT欠損症のようにフェノタイプおよびサブタイプ間でVTEリスクが異なる場合を除いて，あえて実施する必要はない．

参考文献

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