臨床検査60巻1号

2016年01月発行

今月の特集2 グローバル化時代の耐性菌感染症

基質特異性拡張型βラクタマーゼ産生菌

著者： 石井良和¹

所属機関： ¹東邦大学医学部　微生物・感染症学講座　感染制御学分野

ページ範囲：P.84 - P.90

Point

●基質特異性拡張型βラクタマーゼ（ESBL）は，オキシイミノ基を有する第三世代・第四世代セファロスポリン系薬およびモノバクタム系薬を分解し，これらの抗菌薬に対する耐性を付与する．

●ESBLの主要産生菌は大腸菌，肺炎桿菌，Proteus mirabilisなどの腸内細菌科細菌である．

●ESBL産生菌は，院内・外来のいずれからも分離される耐性菌である．

●検出される主要なESBLはCTX-M-型であり，同酵素産生大腸菌の多くがフルオロキノロン系薬にも耐性を示す．

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