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雑誌文献

臨床検査62巻1号

2018年01月発行

文献概要

今月の特集2 心腎連関を理解する

貧血と心腎連関

著者: 今井圓裕1

所属機関: 1中山寺いまいクリニック

ページ範囲:P.78 - P.83

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●慢性心不全,慢性腎不全は貧血を合併することが多い.

●慢性心不全では鉄欠乏状態にある患者が多く,鉄剤の投与によって心不全は改善する可能性がある.

●慢性腎不全ではエリスロポエチンの相対的欠乏による貧血が多い.

●エリスロポエチンを使用した貧血治療はヘモグロビン(Hb)11.0g/dL未満で開始し,Hb13.0g/dLを超えないように注意する.

参考文献

1)Silverberg DS, Wexler D, Blum M, et al:The effect of correction of anaemia in diabetics and non-diabetics with severe resistant congestive heart failure and chronic renal failure by subcutaneous erythropoietin and intravenous iron. Nephrol Dial Transplant 18:141-146,2003
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17)Kuriyama S, Tomonari H, Yoshida H, et al:Reversal of anemia by erythropoietin therapy retards the progression of chronic renal failure, especially in nondiabetic patients. Nephron 77:176-185,1997
18)Tsubakihara Y, Gejyo F, Nishi S, et al:High target hemoglobin with erythropoiesis-stimulating agents has advantages in the renal function of non-dialysis chronic kidney disease patients. Ther Apher Dial 16:529-540,2012
19)Tsubakihara Y, Akizawa T, Iwasaki M, et al:High Hemoglobin Levels Maintained by an Erythropoiesis-Stimulating Agent Improve Renal Survival in Patients with Severe Renal Impairment. Ther Apher Dial 19:457-465,2015
20)Imai E, Maruyama S, Nangaku M, et al:Rationale and study design of a randomized controlled trial to assess the effects of maintaining hemoglobin levels using darbepoetin alfa on prevention of development of end-stage kidney disease in non-diabetic CKD patients (PREDICT Trial). Clin Exp Nephrol 20:71-76,2016
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22)Swedberg K, Young JB, Anand IS, et al:Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med 368:1210-1219,2013

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

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