icon fsr

文献詳細

雑誌文献

臨床検査62巻11号

2018年11月発行

文献概要

今月の特集1 循環癌細胞(CTC)とリキッドバイオプシー

固形癌を対象としたリキッドバイオプシーの臨床応用

著者: 西尾和人1 坂井和子1

所属機関: 1近畿大学医学部ゲノム生物学

ページ範囲:P.1451 - P.1458

文献購入ページに移動
Point

●循環腫瘍DNA(ctDNA)は,デジタルPCRや次世代シークェンサー(NGS)を用いて分子プロファイリングが可能である.

●リキッドバイオプシー(LB)は,治療効果予測,治療経過中のモニタリングツールとして,その臨床的有用性が示されている.

●肺癌EGFR遺伝子変異検査の血漿検査が承認され,用いられている.

参考文献

1)Takahama T, Sakai K, Takeda M, et al:Detection of the T790M mutation of EGFR in plasma of advanced non-small cell lung cancer patients with acquired resistance to tyrosine kinase inhibitors (West Japan oncology group 8014LTR study). Oncotarget 7:58492-58499,2016
2)Matsuo N, Azuma K, Sakai K, et al:Association of EGFR Exon 19 Deletion and EGFR-TKI Treatment Duration with Frequency of T790M Mutation in EGFR-Mutant Lung Cancer Patients. Sci Rep 6:36458,2016
3)Ohira T, Sakai K, Matsubayashi J, et al:Tumor volume determines the feasibility of cell-free DNA sequencing for mutation detection in non-small cell lung cancer. Cancer Sci 107:1660-1666,2016
4)Takano T, Tsurutani J, Takahashi M, et al:A randomized phase Ⅱ trial of trastuzumab plus capecitabine versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer previously treated with trastuzumab and taxanes: WJOG6110B/ELTOP. Breast 40:67-75,2018
5)Sakai H, Tsurutani J, Iwasa T, et al:HER2 genomic amplification in circulating tumor DNA and estrogen receptor positivity predict primary resistance to trastuzumab emtansine (T-DM1) in patients with HER2-positive metastatic breast cancer. Breast Cancer 25:1-9,2018
6)Diaz LA Jr, Williams RT, Wu J, et al:The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486:537-540,2012
7)Shitara K, Yonesaka K, Denda T, et al:Randomized study of FOLFIRI plus either panitumumab or bevacizumab for wild-type KRAS colorectal cancer-WJOG 6210G. Cancer Sci 107:1843-1850,2016
8)Sakai K, Tsurutani J, Yamanaka T, et al:Extended RAS and BRAF Mutation Analysis Using Next-Generation Sequencing. PLoS One 10:e0121891,2015
9)Chabon JJ, Simmons AD, Lovejoy AF, et al:Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients. Nat Commun 7:11815,2016
10)Iwama E, Sakai K, Azuma K, et al:Monitoring of somatic mutations in circulating cell-free DNA by digital PCR and next-generation sequencing during afatinib treatment in patients with lung adenocarcinoma positive for EGFR activating mutations. Ann Oncol 28:136-141,2017

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?