臨床検査62巻9号

2018年09月発行

今月の特集2 知っておきたい遺伝性不整脈

QT短縮症候群

著者： 堀江稔¹

所属機関： ¹滋賀医科大学呼吸循環器内科

ページ範囲：P.1056 - P.1062

Point

●QT短縮症候群（SQTS）の特徴は，①12誘導心電図で著しいQT短縮，②基礎心疾患を有しない心室性不整脈，③突然死の家族歴である．

●どの程度のQTc時間が有意にQT短縮といえるかについては多くの議論があり，診断基準ごとに異なる．

●筆者らの病院ベースの研究で，114,334人の受診者のQTcを調べたところ，全体の0.15％以下となる短いQTc値は，男性で362ms，女性で369msであった．

●診断にはGollobスコアが用いられ，①心電図診断（QT時間），②臨床症状，③家族歴，④遺伝子検査の4項目について点数加算制となっている．

●SQTSでは，QT時間の短縮に加えて，心拍の変化に対するQT時間の応答が少ないことも特徴である．

参考文献

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