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文献概要

今月の特集1 免疫チェックポイント阻害薬—押さえるべき特徴と注意点

免疫チェックポイント阻害薬と感染症

著者: 大串大輔1

所属機関: 1がん研究会有明病院感染症科

ページ範囲:P.39 - P.43

Point

●免疫チェックポイント阻害薬(ICI)の使用そのものが感染症のリスクとなるかははっきりしない.

●免疫関連有害事象(irAE)に対する治療としての免疫抑制剤の使用は,感染症のリスクとなる.

●irAEと感染症の鑑別は困難な場合が多い.

●irAEに対して免疫抑制剤を使用している患者では,細胞性免疫障害に関連した感染症の発生に注意する.

参考文献

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2)Del Castillo M, Romero FA, Argüello E, et al:The Spectrum of Serious Infections Among Patients Receiving Immune Checkpoint Blockade for the Treatment of Melanoma. Clin Infect Dis 63:1490-1493,2016
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8)Weber JS, Hodi FS, Wolchok JD, et al:Safety Profile of Nivolumab Monotherapy: A Pooled Analysis of Patients With Advanced Melanoma. J Clin Oncol 35:785-792,2017
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10)Brahmer JR, Lacchetti C, Schneider BJ, et al:Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol 36:1714-1768,2018
11)Lindsey RB, Sanker S, Nikolaos GA, et al:NCCN Clinical Practice Guidelines in Oncology. Prevention and Treatment of Cancer-Related Infections, version 1,2019

掲載雑誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

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