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雑誌文献

臨床検査64巻3号

2020年03月発行

文献概要

今月の特集2 質量分析を利用した臨床検査

質量分析法を用いた微量薬物投与の血清モニタリング

著者: 井之上浩一1

所属機関: 1立命館大学薬学部臨床分析化学研究室

ページ範囲:P.272 - P.278

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●液体クロマトグラフィー質量分析法(LC-MS)は臨床分野で広く用いられ,その応用として治療薬物モニタリング(TDM)へと発展している.

●最近のLC-MSを用いたTDMにおける研究報告を紹介する.

●疼痛緩和TDMのLC-MSモニタリングの実例を示す.

参考文献

1)Adaway JE, Keevil BG, Owen LJ:Liquid chromatography tandem mass spectrometry in the clinical laboratory. Ann Clin Biochem 52:18-38,2015
2)Eliasson E, Lindh JD, Malmström RE, et al:Therapeutic drug monitoring for tomorrow. Eur J Clin Pharmacol 69(Suppl 1):25-32,2013
3)Avataneo V, D'Avolio A, Cusato J, et al:LC-MS application for therapeutic drug monitoring in alternative matrices. J Pharm Biomed Anal 166:40-51,2019
4)Antunes MV, Charão MF, Linden R:Dried blood spots analysis with mass spectrometry: Potentials and pitfalls in therapeutic drug monitoring. Clin Biochem 49:1035-1046,2016
5)Nys G, Kok MGM, ServaisAC, et al:Beyond dried blood spot: current microsampling techniques in the context of biomedical applications. Trac Trends Anal Chem 97:326-332,2017
6)Martens-Lobenhoffer J, Monastyrski D, Tröger U, et al:Stability of meropenem in plasma versus dried blood spots (DBS). J Pharm Biomed Anal 170:279-284,2019
7)Ialongo C, Mozzi AF, Bernardini S:An LC-MS Assay with Isocratic Separation and On-line Solid Phase Extraction to Improve the Routine Therapeutic Drug Monitoring of Busulfan in Plasma. J Med Biochem 36:113-121,2017
8)Gong ZS, Wu ZH, Xu SX, et al:A high-throughput LC-MS/MS method for the quantification of four immunosu- ppressants drugs in whole blood. Clin Chim Acta 498:21-26,2019
9)Zheng YZ, Wang S:Advances in antifungal drug measurement by liquid chromatography-mass spectrometry. Clin Chim Acta 491:132-145,2019
10)Willeman T, Jourdil JF, Gautier-Veyret E, et al:A multiplex liquid chromatography tandem mass spectrometry method for the quantification of seven therapeutic monoclonal antibodies: Application for adalimumab therapeutic drug monitoring in patients with Crohn's disease. Anal Chim Acta 1067:63-70,2019
11)El Amrani M, Bosman SM, Egas AC, et al:Simultaneous Quantification of Free Adalimumab and Infliximab in Human Plasma Using a Target-Based Sample Purification and Liquid Chromatography-Tandem Mass Spectrometry. Ther Drug Monit 41:640-647,2019
12)Inoue K, Ozawa Y, Toyo'oka T:Application of liquid chromatography coupled with electrospray ionization tandem mass spectrometry for therapeutic drug monitoring of sedative medicine in clinical stage. Chromatography 36:81-92,2015
13)Fujita Y, Yoshizawa S, Hoshika M, et al:Effect of different surgical procedures on the accuracy of prediction of the plasma concentration of fentanyl: comparison between mastectomy and laparoscopic prostatectomy. JA Clin Rep 3:30,2017
14)井之上浩一,松下祥子,野村基雄,他:液体クロマトグラフィー質量分析法によるがん患者の血清中フェンタニル濃度の測定.日緩和医療薬誌 4:111-116,2011

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

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