臨床検査64巻7号

2020年07月発行

今月の特集1 骨髄不全症の病態と検査

—再生不良性貧血—免疫病態

著者： 山﨑宏人¹

所属機関： ¹金沢大学附属病院輸血部

ページ範囲：P.734 - P.739

Point

●再生不良性貧血（AA）の発症にT細胞を介した免疫学的機序の関与を示唆する知見は多い．

●なかでも，“グリコシルホスファチジルイノシトール（GPI）アンカー膜蛋白が欠失した発作性夜間ヘモグロビン尿症（PNH）型血球”や“6pUPDによるヒト白血球抗原（HLA）-クラスⅠアレル欠失血球”の出現は，細胞傷害性T細胞（CTL）による免疫学的攻撃の関与を強く示唆する重要な現象である．

●炎症性サイトカインであるインターフェロン-γ（IFN-γ）も造血抑制にかかわっている．

●制御性T細胞（Treg）やmiRNAはT細胞活性化の調整にかかわっている．

参考文献

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