臨床検査64巻9号

2020年09月発行

今月の特集1 やっぱり大事なCRP

CRPなどの急性期蛋白の産生機序

著者： 萩原圭祐¹

所属機関： ¹大阪大学大学院医学系研究科先進融合医学共同研究講座

ページ範囲：P.938 - P.945

Point

●急性期蛋白の発現には，インターロイキン（IL）-6，IL-1，腫瘍壊死因子α（TNF-α）などの炎症性サイトカインが重要である．その際，IL-6は組み合わせ刺激の中心的な役割を果たす．

●IL-6とIL-1によるC反応性蛋白質（CRP）の転写発現は，刺激早期では阻害的に働き，刺激後期では相乗的に働く．

●IL-6とIL-1による刺激後期のCRPの相乗発現は，IL-6刺激の下流の転写因子であるシグナル伝達兼転写活性化因子3（STAT3）とIL-1下流の転写因子であるc-fosの転写複合体形成が必要である．

●CRPは，免疫系の細胞，サイトカイン，転写因子が総動員され誘導される．検査値をみながら病態を理解し，その原因を深く考察することが，よりよい治療につながる．

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