臨床検査66巻11号

2022年11月発行

今月の特集 マイクロバイオーム

Microbiomeと糖尿病

著者： 渡邊善之¹ 藤坂志帆¹ 戸邉一之¹

所属機関： ¹富山大学学術研究部医学系第一内科

ページ範囲：P.1328 - P.1333

Point

●肥満や糖尿病といった病態では多様性の低下などの腸内細菌叢の破綻（dysbiosis）がみられ，糖代謝異常の発生や増悪の原因となる．

●短鎖脂肪酸，胆汁酸（BA），イミダゾールプロピオン酸をはじめとする腸内細菌由来代謝産物は宿主の耐糖能に影響を与える．

●ヒトの常在菌であるAkkermansia muciniphilaは腸管バリア機能維持に重要な役割を果たす菌であり，代謝異常への治療応用が期待されている．

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