臨床検査66巻11号

2022年11月発行

今月の特集 マイクロバイオーム

Microbiomeと肥満症

著者： 羽石悠里¹ 宮本潤基¹ 木村郁夫¹²

所属機関： ¹東京農工大学大学院農学研究院応用生命化学プログラム ²京都大学大学院生命科学研究科生体システム学分野

ページ範囲：P.1334 - P.1339

Point

●肥満者の腸内細菌はFirmicutes/Bacteroidetesの比率が増加する．

●腸内細菌の主要な代謝物である短鎖脂肪酸（SCFAs）はGPR41とGPR43を介して肥満症状を改善する．

●妊娠期における難消化性多糖やSCFAsの摂取は，次世代の出生以降の成長に伴う肥満に対して抵抗性に寄与する．

参考文献

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