臨床検査66巻11号

2022年11月発行

今月の特集 マイクロバイオーム

Microbiomeと心血管系疾患

著者： 山下智也¹ 吉田尚史¹ 平田健一¹

所属機関： ¹神戸大学大学院医学研究科内科学講座循環器内科学分野

ページ範囲：P.1346 - P.1351

Point

●循環器疾患でも，疾患に特徴的な腸内細菌叢が報告されている．

●腸内細菌は代謝と免疫機能への影響によって宿主の生体機能に影響を及ぼす．

●循環器疾患の発症や予後に腸内細菌代謝物（TMAO）が関係している．

参考文献

1）Emoto T, Yamashita T, Sasaki N, et al：Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease. J Atheroscler Thromb　23：908-921，2016

2）Yoshida N, Emoto T, Yamashita T, et al：Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis. Circulation　138：2486-2498，2018

3）Hayashi T, Yamashita T, Watanabe H, et al：Gut Microbiome and Plasma Microbiome-Related Metabolites in Patients With Decompensated and Compensated Heart Failure. Circ J　83：182-192，2018

4）Emoto T, Hayashi T, Tabata T, et al：Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure. Int J Cardiol　338：138-142，2021

5）Hayashi T, Yamashita T, Takahashi T, et al：Uncovering the Role of Gut Microbiota in Amino Acid Metabolic Disturbances in Heart Failure Through Metagenomic Analysis. Front Cardiovasc Med　8：789325，2021

6）Tabata T, Yamashita T, Hosomi K, et al：Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs. Heart Vessels　36：105-114，2021

7）平田健一，山下智也：腸内細菌と循環器疾患．日内会誌　107：1906-1912，2018

8）山下智也，平田健一：腸内細菌と循環器疾患．日医師会誌　149：1583-1587，2020

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11）Yamashiro K, Tanaka R, Urabe T, et al：Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke. PLoS One　12：e0171521，2017

12）Huang K, Wang Y, Bai Y, et al：Gut Microbiota and Metabolites in Atrial Fibrillation Patients and Their Changes after Catheter Ablation. Microbiol Spectr　10：e0107721，2022

13）Wang Z, Klipfell E, Bennett BJ, et al：Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature　472：57-63，2011

14）Wang Z, Roberts AB, Buffa JA, et al：Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. Cell　163：1585-1595，2015

15）Tang WH, Wang Z, Fan Y, et al：Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis. J Am Coll Cardiol　64：1908-1914，2014