icon fsr

雑誌詳細

文献概要

今月の特集 腫瘍随伴症候群 免疫学的機序によるもの

傍腫瘍性小脳変性症

著者: 東光久1

所属機関: 1地方独立行政法人 奈良県立病院機構 奈良県総合医療センター 総合診療科

ページ範囲:P.1266 - P.1270

Point

●傍腫瘍性小脳変性症(PCD)とは,癌に関連して発症する小脳失調を主体とした,まれな腫瘍随伴症候群の1つである.

●PCD診断時は,癌が顕在化していないことが多く,その場合は癌の存在の有無も精査する必要がある.

●PCDに免疫療法は無効であることが多く,他の治療可能な疾患を除外することが何より重要である.

参考文献

1)Dalmau J, Rosenfeld MR:Paraneoplastic cerebellar degeneration. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc.(https://www.uptodate.com/contents/paraneoplastic-cerebellar-degeneration)(最終アクセス:2023年9月14日)
2)田中惠子:傍腫瘍性神経症候群と抗神経抗体.臨神経 50:371-378,2010
3)Verschuuren J, Chuang L, Rosenblum MK, et al:Inflammatory infiltrates and complete absence of Purkinje cells in anti-Yo-associated paraneoplastic cerebellar degeneration. Acta Neuropathol 91:519-525,1996
4)Greene M, Lai Y, Baella N, et al:Antibodies to Delta/notch-like epidermal growth factor-related receptor in patients with anti-Tr, paraneoplastic cerebellar degeneration, and Hodgkin lymphoma. JAMA Neurol 71:1003-1008,2014
5)Hammack J, Kotanides H, Rosenblum MK, et al:Paraneoplastic cerebellar degeneration. II. Clinical and immunologic findings in 21 patients with Hodgkin's disease. Neurology 42:1938-1943,1992
6)Lopez-Chiriboga AS, Komorowski L, Kümpfel T, et al:Metabotropic glutamate receptor type 1 autoimmunity: Clinical features and treatment outcomes. Neurology 86:1009-1013,2016
7)Mason WP, Graus F, Lang B, et al:Small-cell lung cancer, paraneoplastic cerebellar degeneration and the Lambert-Eaton myasthenic syndrome. Brain 120(Pt 8):1279-1300,1997
8)Graus F, Lang B, Pozo-Rosich P, et al:P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer. Neurology 59:764-766,2002
9)Shams'ili S, Grefkens J, de Leeuw B, et al:Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients. Brain 126(Pt 6):1409-1418,2003
10)Le May M, Dent S:Anti-Yo antibody-mediated paraneoplastic cerebellar degeneration associated with cognitive affective syndrome in a patient with breast cancer: a case report and literature review. Curr Oncol 25:e585-e591,2018
11)Peterson K, Rosenblum MK, Kotanides H, et al:Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients. Neurology 42:1931-1937,1992
12)Dalmau J, Gonzalez RG, Lerwill MF:Case records of the Massachusetts General Hospital. Case 4-2007. A 56-year-old woman with rapidly progressive vertigo and ataxia. N Engl J Med 356:612-620,2007
13)Scheid R, Voltz R, Briest S, et al:Clinical insights into paraneoplastic cerebellar degeneration. J Neurol Neurosurg Psychiatry 77:529-530,2006
14)Widdess-Walsh P, Tavee JO, Schuele S, et al:Response to intravenous immunoglobulin in anti-Yo associated paraneoplastic cerebellar degeneration: case report and review of the literature. J Neurooncol 63:187-190,2003
15)Sillevis Smitt P, Kinoshita A, De Leeuw B, et al:Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N Engl J Med 342:21-27,2000
16)Do LD, Gupton SL, Tanji K, et al:TRIM9 and TRIM67 Are New Targets in Paraneoplastic Cerebellar Degeneration. Cerebellum 18:245-254,2019
17)de la Sayette V, Bertran F, Honnorat J, et al:Paraneoplastic cerebellar syndrome and optic neuritis with anti-CV2 antibodies: clinical response to excision of the primary tumor. Arch Neurol 55:405-408,1998
18)Briani C, Vitaliani R, Grisold W, et al:Spectrum of paraneoplastic disease associated with lymphoma. Neurology 76:705-710,2011
19)Graus F, Dalmau J, Valldeoriola F, et al:Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin's disease. J Neuroimmunol 74:55-61,1997
20)Honnorat J, Cartalat-Carel S, Ricard D, et al:Onco-neural antibodies and tumour type determine survival and neurological symptoms in paraneoplastic neurological syndromes with Hu or CV2/CRMP5 antibodies. J Neurol Neurosurg Psychiatry 80:412-416,2009
21)Rojas I, Graus F, Keime-Guibert F, et al:Long-term clinical outcome of paraneoplastic cerebellar degeneration and anti-Yo antibodies. Neurology 55:713-715,2000
22)Cao Y, Abbas J, Wu X, et al:Anti-Yo positive paraneoplastic cerebellar degeneration associated with ovarian carcinoma: case report and review of the literature. Gynecol Oncol 75:178-183,1999

掲載雑誌情報

出版社:株式会社医学書院

電子版ISSN:1882-1367

印刷版ISSN:0485-1420

雑誌購入ページに移動
icon up
あなたは医療従事者ですか?