精神医学51巻2号

2009年02月発行

シンポジウム 統合失調症の脳科学

オーバービュー：統合失調症研究の現在

著者： 岡崎祐士¹

所属機関： ¹東京都立松沢病院

ページ範囲：P.151 - P.158

　統合失調症の脳科学的研究課題を，今日の統合失調症の理解と治療にかかわる幾つかのトピックスに触れながら述べることにする。

参考文献

1) Anzai N, Okazaki Y, Miyauchi M, et al：Early neuroleptic medication within one year after onset can reduce risk of later relapses in schizophrenic patients. Ann Rep Pharmachopsychiatr Res Found 25：269-286, 1988

2) Cannon TD, van Erp TG, Bearden CE, et al：Early and late neurodevelopmental influences in the prodrome to schizophrenia：Contributions of genes, environment, and their interactions. Schizophr Bul 29：653-669, 2003

3) Crow TJ, MacMillan JF, Johnson AL, et al：A randomised controlled trial of prophylactic neuroleptic treatment. Br J Psychiatry 148：120-127, 1986

4) Hirayasu Y, McCarley RW, Salisbury DF, et al：Planum temporale and Heschl gyrus volume reduction in schizophrenia：A magnetic resonance imaging study of first-episode patients. Arch Gen Psychiatry 57：692-699, 2000

5) Jablensky A, Sartorius N, Ernberg G, et al：Schizophrenia：Manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monogr 20(Suppl)：1-97, 1992

6) Johnstone EC, Crow TJ, Frith CD, et al：Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet 7992：924-926, 1976

7) Kasai K, Shenton ME, Salisbury DF, et al：Progressive decrease of left Heschl gyrus and planum temporale gray matter volume in first-episode schizophrenia：A longitudinal magnetic resonance imaging study. Arch Gen Psychiatry 60：766-775, 2003

8) Lieberman JA, Perkins D, Belger A, et al：The early stages of schizophrenia：Speculations on pathogenesis, pathophysiology, and therapeutic approaches. Biol Psychiatry 50：884-897, 2001

9) McGorry P, Purcell R, Hickle IB, et al：Clinical staging：A heulistic model for psychiatry and youth mental health. Med J Aus 187：S40-S42, 2007

10) Nishida A, Tanii H, Nishimura Y, et al：Associations between psychotic-like experiences and mental health status and other psychopathologies among Japanese early teens. Schizophr Res 99：125-133, 2008

11) 西川徹：Schizophreniaの分子病態．星和書店，2004

12) 岡崎祐士：精神分裂病の「脳病変」は発見されたのか？　臨精医 38：1585-1592，1999

13) ORYGEN Youth Health：The acute phase of early psychosis：A handbook on management. Melbourne. ORYGEN Research Centre, Melbourne, 2004

14) Poulton R, Caspi A, Moffitt TE, et al：Children's self-reported psychotic symptoms and adult schizophreniform disorder：A 15-year longitudinal study. Arch Gen Psychiatry 57：1053-1058, 2000

15) Saijo T, Abe T, Someya Y, et al：Ten year progressive ventricular enlargement in schizophrenia：An MRI morphometrical study. Psychiatry Clin Neurosci 55：41-47, 2001

16) Takahashi T, Suzuki M, Tanino R, et al：Volume reduction of the left planum temporale gray matter associated with long duration of untreated psychosis in schizophrenia：A preliminary report. Psychiatry Res 154：209-219, 2007