精神医学57巻10号

2015年10月発行

特集 精神医学と神経学の境界領域—最近のトピックスから

TDP-43陽性封入体を有する前頭側頭葉変性症(FTLD-TDP)の臨床的特徴

著者： 横田修¹²

所属機関： ¹きのこエスポアール病院 ²岡山大学大学院医歯薬学総合研究科精神神経病態学

ページ範囲：P.839 - P.847

文献概要

はじめに
　前頭側頭葉変性症(frontotemporal lobar degeneration；FTLD)とは，前頭葉と側頭葉に比較的限局した機能障害を来す病理学的疾患単位群の総称である。このうちリン酸化TDP-43蛋白が異常に凝集し蓄積したTDP-43陽性封入体を有すFTLDはFTLD-TDPと呼ばれる^2,10)。本稿ではその臨床像を主にピック病と比較しながら解説する。

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