精神医学57巻6号

2015年06月発行

試論

「脆弱性ストレス-情報伝達障害モデル」による統合失調症発症機序解明の試み

著者： 中西伸介¹ 山中康裕²³

所属機関： ¹矢作川病院 ²京都大学 ³京都ヘルメス研究所

ページ範囲：P.451 - P.459

抄録
　統合失調症の発症機序について種々の仮説はあるもの，いまだ不明なところが多い。そこでこれまでの多くの研究に基づいて，従来の「脆弱性ストレスモデル」を発展させた新たなモデル「脆弱性ストレス-情報伝達障害モデル」を提案した。本モデルは「脳の情報処理過程において，ストレス情報の情動ネットワーク思考ネットワークへの伝達が障害されることにより，ストレスから個体が保護される一方で，情報伝達障害および情報伝達障害による情報統合の破綻により統合失調症が発症する」という仮説を基本とする。このモデルによって統合失調症の臨床症状を論理的に説明できるか否かが，生物学的方法では困難な本モデルの信頼性検証の一方法となる。

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