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文献詳細

雑誌文献

精神医学60巻3号

2018年03月発行

文献概要

特集 せん妄をめぐる最近の動向

アルコール離脱せん妄

著者: 木村充1

所属機関: 1国立病院機構久里浜医療センター精神科

ページ範囲:P.243 - P.252

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はじめに
 2013年に行われた疫学調査によれば,アルコール依存症疑いの患者は全国に108万人いると推定されている。アルコールはさまざまな身体疾患を引き起こし,また転倒,転落などの事故のリスクも高いため,救急受診につながりやすい。そのため,アルコール離脱はさまざまな科で遭遇することの多い病態である。
 アルコール離脱によるせん妄は振戦せん妄とも呼ばれ,アルコール離脱てんかんと並んでアルコール離脱の最も重症な形態である。振戦せん妄は,救急医療や集中治療室での対応困難を引き起こすだけではなく,致死的となる可能性もあるため,的確な診断とマネジメントの必要性は高い。本稿では,アルコール離脱せん妄の病態,治療についての概要を述べたい。

参考文献

1)Amato L, Minozzi S, Davoli M:Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome. Cochrane Database Syst Rev:CD008537, 2011
2)Amato L, Minozzi S, Vecchi S, et al:Benzodiazepines for alcohol withdrawal. Cochrane Database Syst Rev:CD005063, 2010
3)Barrons R, Roberts N:The role of carbamazepine and oxcarbazepine in alcohol withdrawal syndrome. J Clin Pharm Ther 35:153-167, 2010
4)Becker HC:Kindling in alcohol withdrawal. Alcohol Health Res World 22:25-33, 1998
5)Eyer F, Schuster T, Felgenhauer N, et al:Risk assessment of moderate to severe alcohol withdrawal--predictors for seizures and delirium tremens in the course of withdrawal. Alcohol Alcohol 46:427-433, 2011
6)Fiellin DA, O'Connor PG, Holmboe ES, et al:Risk for delirium tremens in patients with alcohol withdrawal syndrome. Subst Abus 23:83-94, 2002
7)Gold JA, Rimal B, Nolan A, et al:A strategy of escalating doses of benzodiazepines and phenobarbital administration reduces the need for mechanical ventilation in delirium tremens. Crit Care Med 35:724-730, 2007
8)Kattimani S, Bharadwaj B:Clinical management of alcohol withdrawal:A systematic review. Ind Psychiatry J 22:100-108, 2013
9)Leone MA, Vigna-Taglianti F, Avanzi G, et al:Gamma-hydroxybutyrate(GHB)for treatment of alcohol withdrawal and prevention of relapses. Cochrane Database Syst Rev:CD006266, 2010
10)Lyon JE, Khan RA, Gessert CE, et al:Treating alcohol withdrawal with oral baclofen:a randomized, double-blind, placebo-controlled trial. J Hosp Med 6:469-474, 2011
11)Mainerova B, Prasko J, Latalova K, et al:Alcohol withdrawal delirium-diagnosis, course and treatment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 159:44-52, 2015
12)Maldonado JR, Sher Y, Ashouri JF, et al:The “Prediction of Alcohol Withdrawal Severity Scale”(PAWSS):systematic literature review and pilot study of a new scale for the prediction of complicated alcohol withdrawal syndrome. Alcohol 48:375-390, 2014
13)Mayo-Smith MF:Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. JAMA 278:144-151, 1997
14)Mayo-Smith MF, Beecher LH, Fischer TL, et al:Management of alcohol withdrawal delirium. An evidence-based practice guideline. Arch Intern Med 164:1405-1412, 2004
15)McCowan C, Marik P:Refractory delirium tremens treated with propofol:a case series. Crit Care Med 28:1781-1784, 2000
16)Mirijello A, D'Angelo C, Ferrulli A, et al:Identification and management of alcohol withdrawal syndrome. Drugs 75:353-365, 2015
17)Mo Y, Thomas MC, Karras GE, Jr. :Barbiturates for the treatment of alcohol withdrawal syndrome:A systematic review of clinical trials. J Crit Care 32:101-107, 2016
18)Rustembegovic A, Sofic E, Kroyer G:A pilot study of Topiramate(Topamax)in the treatment of tonic-clonic seizures of alcohol withdrawal syndromes. Med Arh 56:211-212, 2002
19)Sachdeva A, Chandra M, Deshpande SN:A comparative study of fixed tapering dose regimen versus symptom-triggered regimen of lorazepam for alcohol detoxification. Alcohol Alcohol 49:287-291, 2014
20)Sachdeva A, Choudhary M, Chandra M:Alcohol Withdrawal Syndrome:Benzodiazepines and Beyond. J Clin Diagn Res9:VE01-VE07, 2015
21)Saitz R, Mayo-Smith MF, Roberts MS, et al:Individualized treatment for alcohol withdrawal. A randomized double-blind controlled trial. JAMA 272:519-523, 1994
22)Schuckit MA:Recognition and management of withdrawal delirium(delirium tremens). N Engl J Med 371:2109-2113, 2014
23)Trevisan LA, Boutros N, Petrakis IL, et al:Complications of alcohol withdrawal:pathophysiological insights. Alcohol Health Res World 22:61-66, 1998
24)Voris J, Smith NL, Rao SM, et al:Gabapentin for the treatment of ethanol withdrawal. Subst Abus 24:129-132, 2003
25)Weintraub SJ:Diazepam in the Treatment of Moderate to Severe Alcohol Withdrawal. CNS Drugs 31:87-95, 2017

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-126X

印刷版ISSN:0488-1281

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