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雑誌文献

精神医学61巻4号

2019年04月発行

文献概要

特集 統合失調症の治療ゴールをめぐって

早期介入・早期支援の視点から—統合失調症の治療ゴールの検討

著者: 松本和紀1 冨本和歩1 佐藤祐太朗1 大野高志2

所属機関: 1東北大学大学院医学系研究科精神神経学分野 2宮城県立精神医療センター

ページ範囲:P.411 - P.421

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抄録 本稿では,はじめに初回エピソード精神病(first episode psychosis:FEP)に対する早期介入サービスの成果と現在の課題について論じ,その後,FEPの治療における抗精神病薬の役割について最近の研究を紹介し,治療ゴールの視点から検討を加えた。さらに,精神病に移行するリスクの高い臨床的ハイリスク(clinical high risk:CHR)状態について,精神病への移行を過度に重視することの問題点とその治療について論じた。最後に,早期介入にかかわる医療スタッフからみた,統合失調症の治療ゴールについて意見を紹介した。精神疾患の早期段階からの経過は多様性が高く,その後の治療や環境の影響を受けて変化する余地は大きい。古典的な医学モデルに基づく信念や偏見によって,当事者の治療ゴールの可能性を狭めるべきではない。臨床的リカバリーとパーソナルリカバリーを統合的に実現していくための支援を早期から行う実践とそのための新たな研究に期待したい。

参考文献

1)Birchwood M, Todd P, Jackson C:Early intervention in psychosis. The critical period hypothesis. Br J Psychiatry Suppl 172:53-59, 1998
2)Fusar-Poli P, McGorry PD, Kane JM:Improving outcomes of first-episode psychosis:an overview. World Psychiatry 16:251-265, 2017
3)McCrone P, Craig TK, Power P, et al:Cost-effectiveness of an early intervention service for people with psychosis. Br J Psychiatry 196:377-382, 2010
4)Addington DE, McKenzie E, Norman R, et al:Essential evidence-based components of first-episode psychosis services. Psychiatr Serv 64:452-457, 2013
5)National Institute for Health and Care Excellence:Psychosis and schizophrenia in adults:Prevention and management. National Institute for Health and Care Excellence, London, 2014
6)Bertelsen M, Jeppesen P, Petersen L, et al:Five-year follow-up of a randomized multicenter trial of intensive early intervention vs standard treatment for patients with a first episode of psychotic illness:the OPUS trial. Arch Gen Psychiatry 65:762-771, 2008
7)Gafoor R, Nitsch D, McCrone P, et al:Effect of early intervention on 5-year outcome in non-affective psychosis. Br J Psychiatry 196:372-376, 2010
8)Chang WC, Kwong VW, Chan GH, et al:Prediction of functional remission in first-episode psychosis:12-month follow-up of the randomized-controlled trial on extended early intervention in Hong Kong. Schizophr Res 173:79-83, 2016
9)Malla A, Joober R, Iyer S, et al:Comparing three-year extension of early intervention service to regular care following two years of early intervention service in first-episode psychosis:a randomized single blind clinical trial. World Psychiatry 16:278-286, 2017
10)Albert N, Melau M, Jensen H, et al:Five years of specialised early intervention versus two years of specialised early intervention followed by three years of standard treatment for patients with a first episode psychosis:randomised, superiority, parallel group trial in Denmark(OPUS II). BMJ 356:i6681, 2017
11)Austin SF, Mors O, Budtz-Jorgensen E, et al:Long-term trajectories of positive and negative symptoms in first episode psychosis:A 10year follow-up study in the OPUS cohort. Schizophr Res 168:84-91, 2015
12)Fowler D, Hodgekins J, French P, et al:Social recovery therapy in combination with early intervention services for enhancement of social recovery in patients with first-episode psychosis(SUPEREDEN3):a single-blind, randomised controlled trial. Lancet Psychiatry 5:41-50, 2018
13)Ciompi L and Hoffmann H:Soteria Berne:an innovative milieu therapeutic approach to acute schizophrenia based on the concept of affect-logic. World Psychiatry 3:140-146, 2004
14)Morrison AP, Turkington D, Pyle M, et al:Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs:a single-blind randomised controlled trial. Lancet 383:1395-1403, 2014
15)Morrison AP, Law H, Carter L, et al:Antipsychotic drugs versus cognitive behavioural therapy versus a combination of both in people with psychosis:a randomised controlled pilot and feasibility study. Lancet Psychiatry 5:411-423, 2018
16)Leucht S, Cipriani A, Spineli L, et al:Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia:a multiple-treatments meta-analysis. Lancet 382:951-962, 2013
17)Murray RM, Quattrone D, Natesan S, et al:Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics? Br J Psychiatry 209:361-365, 2016
18)Tiihonen J, Tanskanen A, Taipale H:20-Year Nationwide Follow-Up Study on Discontinuation of Antipsychotic Treatment in First-Episode Schizophrenia. Am J Psychiatry 175:765-773, 2018
19)Wunderink L, Nieboer RM, Wiersma D, et al:Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy:long-term follow-up of a 2-year randomized clinical trial. JAMA Psychiatry 70:913-920, 2013
20)松本和紀:寛解を維持している初回エピソード統合失調症における抗精神病薬の中止.臨床精神薬理 21:415-418, 2018
21)桂雅宏,阿部光一,國分恭子,他:ARMSへの早期介入—議論の整理と海外ガイドラインの紹介.精神医学 58:571-579, 2016
22)松本和紀:精神病性障害におけるスペクトラム.精神科診断学 9:96-102, 2016
23)van Os J, Guloksuz S:A critique of the “ultra-high risk” and “transition” paradigm. World Psychiatry 16:200-206, 2017
24)Yung AR, Nelson B, Thompson A, et al:The psychosis threshold in Ultra High Risk(prodromal)research:is it valid? Schizophr Res 120:1-6, 2010
25)松本和紀:統合失調症の初期症状—これまでの研究概念の概観.精神科治療学 33:79-85, 2018
26)松本和紀,濱家由美子,冨本和歩:ARMS(アットリスク精神状態)に対する認知行動療法の現状.最新精神医学 23:105-112, 2018
27)Matsumoto K, Ohmuro N, Tsujino N, et al:Open-label study of cognitive behavioural therapy for individuals with at-risk mental state:Feasibility in the Japanese clinical setting. Early Interv Psychiatry 13:137-141, 2019
28)Schmidt SJ, Schultze-Lutter F, Schimmelmann BG, et al:EPA guidance on the early intervention in clinical high risk states of psychoses. Eur Psychiatry 30:388-404, 2015
29)Lally J, Ajnakina O, Stubbs B, et al:Remission and recovery from first-episode psychosis in adults:systematic review and meta-analysis of long-term outcome studies. Br J Psychiatry 211:350-358, 2017

掲載誌情報

出版社:株式会社医学書院

電子版ISSN:1882-126X

印刷版ISSN:0488-1281

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