文献詳細
特集 統合失調症の治療ゴールをめぐって
文献概要
抄録 近年,統合失調症の治療ゴールを考える上で,精神病症状の寛解のみではなく機能的転帰が重要視され,早期介入の効果などが注目される。一方,統合失調症の臨床において,脳画像検査の役割は主に器質因の除外であり,診断や治療効果の判定に有用とは言えない。しかし,磁気共鳴画像などによる脳画像検査が将来的には統合失調症の臨床に応用可能であることを示唆する研究報告が増えつつある。たとえば,統合失調症でみられる脳形態変化は発症に先立ち存在し,それらの一部は将来の臨床経過の予測にある程度役立つ可能性がある。また統合失調症の病初期にみられる進行性の脳形態変化は,臨床症状の形成や社会機能悪化とも関連すると考えられ,病初期における治療標的として有用かもしれない。これらの研究知見は,特に統合失調症の長期的転帰改善を目指す早期介入の分野において今後の臨床応用が期待される。
参考文献
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