精神医学61巻8号

2019年08月発行

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特集 光と精神医学

光の気分への作用

著者： 内山真¹

所属機関： ¹日本大学医学部精神医学系

ページ範囲：P.873 - P.881

抄録　光が気分に与える影響についての記載は古くからあり，文学作品にも多く取り上げられてきた。しかし，臨床医学で取り上げられるようになったのは，1980年代の季節性うつ病の発見からである。光による抗うつ効果については，網膜から視床下部への直接路が発見され，初期には概日リズムや睡眠の改善を介したものと考えられていた。2000年以降になって，網膜から海馬や扁桃体への直接的な伝達経路が発見され，抗うつ効果は抗うつ薬などと基本的に変わらない辺縁系への直接作用によるものが大きいことが分かってきた。本稿では，網膜から辺縁系への投射路の機能から，気分障害における高照度光療法の効果について検討した。

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