精神医学61巻8号

2019年08月発行

特集 光と精神医学

光の非視覚性作用—覚醒度および認知機能の修飾作用

著者： 竹島正浩¹ 三島和夫¹

所属機関： ¹秋田大学大学院医学系研究科精神科学講座

ページ範囲：P.883 - P.889

抄録　光の視覚以外への作用を非視覚作用と呼び，非視覚作用の1つに認知機能に対する作用がある。光の認知機能に対する主な効果は覚醒度の増加と考えられている。一般的に網膜に入射した光は内因性光感受性神経節細胞を介して視交叉上核に到達し，視床，青斑核，皮質など広範な脳部位の賦活により急性の覚醒効果を発揮すると考えられている。光による覚醒効果はより高い照度，より短い波長，およびより高い色温度で覚醒度を高める。光が覚醒水準および認知機能に及ぼす影響とそのメカニズムは未解明な点も多く，さらなるエビデンスの蓄積が求められている。

参考文献

1)Gooley JJ, Rajaratnam SM, Brainard GC, et al：Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light. Sci Transl Med 31：31ra33, 2010

2)Gooley JJ, Ho Mien I, St Hilaire MA, et al：Melanopsin and rod-cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans. J Neurosci 32：14242-14253, 2012

3)Pail G, Huf W, Pjrek E, et al：Bright-light therapy in the treatment of mood disorders. Neuropsychobiol 64：152-162, 2011

4)Chellappa SL, Steiner R, Blattner P, et al：Non-visual effects of light on melatonin, alertness and cognitive performance：can blue-enriched light keep us alert? PLoS One 6：e16429, 2011

5)Vandewalle G, Balteau E, Phillips C, et al：Daytime light exposure dynamically enhances brain responses. Curr Biol 16：1616-1621, 2006

6)Nishida M, Walker MP：Daytime naps, motor memory consolidation and regionally specific sleep spindles. PLoS One 2：e341, 2007

7)Basner M, Rao H, Goel N, et al：Sleep deprivation and neurobehavioral dynamics. Curr Opin Neurobiol 23：854-863, 2013

8)Kyriacou CP, Hastings MH：Circadian clocks：genes, sleep, and cognition. Trends Cogn Sci 14：259-267, 2010

9)Wright KP, Lowry CA, Lebourgeois MK：Circadian and wakefulness-sleep modulation of cognition in humans. Front Mol Neurosci 5：50, 2012

10)Fisk AS, Tam SKE, Brown LA, et al：Light and Cognition：Roles for Circadian Rhythms, Sleep, and Arousal. Front Neurol 9：56, 2018

11)Souman JL, Tinga AM, Te Pas SF, et al：Acute alerting effects of light：A systematic literature review. Behav Brain Res 337：228-239, 2018

12)Berson DM：Strange vision：ganglion cells as circadian photoreceptors. Trends Neurosci 26：314-320, 2003

13)Vandewalle G, Maquet P, Dijk DJ：Light as a modulator of cognitive brain function. Trends Cogni Sci 13：429-438, 2009

14)Brainard GC, Hanifin JP, Greeson JM, et al：Action spectrum for melatonin regulation in humans：evidence for a novel circadian photoreceptor. J Neurosci 21：6405-6412, 2001

15)Thapan K, Arendt J, Skene DJ：An action spectrum for melatonin suppression：evidence for a novel non-rod, non-cone photoreceptor system in humans. J Physiol 535(Pt 1)：261-267, 2001

16)Revell VL, Arendt J, Fogg LF, et al：Alerting effects of light are sensitive to very short wavelengths. Neurosci Lett 399(1-2)：96-100, 2006

17)Revell VL, Barrett DC, Schlangen LJ, et al：Predicting human nocturnal nonvisual responses to monochromatic and polychromatic light with a melanopsin photosensitivity function. Chronobiol Int 27(9-10)：1762-1777, 2010

18)Cajochen C, Munch M, Kobialka S, et al：High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light. J Clin Endocrinol Metab 90：1311-1316, 2005

19)Lockley SW, Evans EE, Scheer FA, Brainard GC, et al：Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. Sleep 29：161-168, 2006

20)Cajochen C, Zeitzer JM, Czeisler CA, et al：Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness. Behav Brain Res 115：75-83, 2000

21)Phipps-Nelson J, Redman JR, Dijk DJ, et al：Daytime exposure to bright light, as compared to dim light, decreases sleepiness and improves psychomotor vigilance performance. Sleep 26：695-700, 2003

22)Smolders KC, de Kort YA, Cluitmans PJ：A higher illuminance induces alertness even during office hours：findings on subjective measures, task performance and heart rate measures. Physiol Behav 107：7-16, 2012

23)Rahman SA, Marcu S, Shapiro CM, et al：Spectral modulation attenuates molecular, endocrine, and neurobehavioral disruption induced by nocturnal light exposure. Am J Physiol Endocrinol Metab 300：E518-E527, 2011

24)Rahman SA, Shapiro CM, Wang F, et al：Effects of filtering visual short wavelengths during nocturnal shiftwork on sleep and performance. Chronobiol Int 30：951-962, 2013

25)Kayumov L, Casper RF, Hawa RJ, et al：Blocking low-wavelength light prevents nocturnal melatonin suppression with no adverse effect on performance during simulated shift work. J Clin Endocrinol Metab 90：2755-2761, 2005

26)van de Werken M, Gimenez MC, de Vries B, et al：Short-wavelength attenuated polychromatic white light during work at night：limited melatonin suppression without substantial decline of alertness. Chronobiol Int 30：843-854, 2013

27)Sasseville A, Martin JS, Houle J, et al：Investigating the contribution of short wavelengths in the alerting effect of bright light. Physiol Behav 151：81-87, 2015

28)Higuchi S, Fukuda T, Kozaki T, et al：Effectiveness of a red-visor cap for preventing light-induced melatonin suppression during simulated night work. J Physiol Anthropol 30：251-258, 2011

29)Alkozei A, Smith R, Dailey NS, et al：Acute exposure to blue wavelength light during memory consolidation improves verbal memory performance. PLoS One 12：e0184884, 2017

30)Cajochen C, Frey S, Anders D, et al：Evening exposure to a light-emitting diodes(LED)-backlit computer screen affects circadian physiology and cognitive performance. J Appl Physiol(1985) 110：1432-1438 , 2011

31)Vandewalle G, Schmidt C, Albouy G, et al：Brain responses to violet, blue, and green monochromatic light exposures in humans：prominent role of blue light and the brainstem. PLoS One 2：e1247, 2007