精神医学61巻8号

2019年08月発行

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特集 光と精神医学

光と加齢・認知症

著者： 金野倫子¹

所属機関： ¹埼玉県立大学保健医療福祉学部共通教育科

ページ範囲：P.915 - P.926

抄録　認知症においては，睡眠覚醒リズムをはじめとした概日リズムの問題に関連すると考えられる行動心理症状(behavioral and psychological symptoms of dementia：BPSD)が少なからず認められる。光は非イメージ形成機能を持ち，体内時計の同調機能はそのひとつであるが，加齢や認知症に伴ってこの機能においていくつものレベルで変化が生じ，結果として光作用減弱をもたらすことが明らかとなっている。一方，体内時計の同調機能や情動などに関連するいくつかの脳部位に対して，網膜からの直接投射経路の存在も見出されている。認知症の睡眠やBPSDへの高照度光療法(bright light therapy：BLT)に対する評価は必ずしも確立されていないが，これまでのBLT研究や上記の知見の中には，光によるBPSD介入をさらに効果的にするヒントがあると考えられる。

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