精神医学61巻8号

2019年08月発行

特集 光と精神医学

不安関連疾患と光

著者： 吉池卓也¹ 栗山健一¹

所属機関： ¹国立精神・神経医療研究センター精神保健研究所睡眠・覚醒障害研究部

ページ範囲：P.927 - P.933

文献概要

抄録　心的外傷後ストレス障害と不安障害群は，過度で持続的な恐怖・不安および回避行動を臨床的特徴として共有し，その多くでストレス・恐怖処理にかかわる神経回路障害が認められる。さらに，これらの障害群は，恐怖条件づけの獲得亢進，般化，および消去不全により特徴付けられる，情動記憶機能障害を有する一群と考えられる。高照度光照射は，海馬依存的学習のみならず，恐怖条件づけを含む扁桃体依存的学習にも影響することが動物・ヒト研究で明らかにされ，恐怖・不安関連病態における高照度光療法の臨床応用が期待される。その際，抗うつ効果を目的とする静的な光照射と対照的に，標的学習過程と同期させる動的な光照射の有用性が示唆される。

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