精神医学64巻6号

2022年06月発行

特集 認知症診療の新潮流—近未来の認知症診療に向けて

アルツハイマー病(AD)に類似した非AD認知症疾患

著者： 山田正仁¹²³

所属機関： ¹国家公務員共済組合連合会九段坂病院内科(脳神経内科) ²東京医科歯科大学 ³金沢大学

ページ範囲：P.877 - P.884

文献概要

抄録　臨床的にアルツハイマー病(AD)と考えられる例の2割前後はアミロイドマーカー陰性で非AD病態と考えられる(suspected non-AD pathophysiology：SNAP)。SNAPの病理学的背景にはタウオパチーである原発性年齢関連タウオパチー(primary age-related tauopathy：PART)と嗜銀顆粒病(argyrophilic grain disease：AGD)，TDP-43蛋白異常症である辺縁系優位型年齢関連TDP-43脳症(limbic predominant age-related TDP-43 encephalopathy：LATE)が含まれる。神経原線維変化型老年期認知症(senile dementia of the neurofibrillary tangle type：SD-NFT)はPART病理による認知症である。本稿ではこれらについて概説した。

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