精神医学66巻2号

2024年02月発行

特集 うつ病のバイオマーカー開発の試み

うつ病のバイオマーカーとしての脳由来神経栄養因子

著者： 𠮷村玲児¹

所属機関： ¹産業医科大学医学部精神医学

ページ範囲：P.137 - P.144

抄録
　うつ病での脳由来神経栄養因子（BDNF）に関して論じた。BDNFは脳脊髄液中，血中（血清・血漿）ともにうつ病では健常者と比較して低下していた。さらに抑うつ状態の程度とも関連している可能性もあり，うつ病のバイオマーカーの1つの候補になりうる可能性がある。BDNFは脳以外の組織でも産生されるために，血中BDNFが脳内動態を反映しているという証左はない。つまり，なぜ末梢BDNF濃度がうつ病で低下しており，治療的介入で増加することに関しての機序は不明である。

参考文献

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