胃と腸38巻4号

2003年04月発行

特集 全身性疾患と消化管病変 各論 3.膠原病，免疫・アレルギー性疾患

4)強皮症（全身性硬化症）

著者： 中村昌太郎¹ 中村滋郎¹ 松本主之¹ 川久保啓司² 八尾隆史³ 飯田三雄¹

所属機関： ¹九州大学大学院医学研究院病態機能内科学 ²筑前山田赤十字病院 ³九州大学大学院医学研究院形態機能病理学

ページ範囲：P.535 - P.541

　強皮症(全身性硬化症)の消化管病変は，固有筋層における膠原線維の増生と筋組織の萎縮に起因する消化管の拡張と蠕動の低下に要約される．食道には50～90％の症例で管腔拡張，食道裂孔ヘルニア，逆流性食道炎などがみられる．胃病変は少なく，小腸には約50％の症例で十二指腸・空腸の拡張や偽性腸閉塞などの病変がみられ，X線では特徴的なhide-bound appearanceやcoiled-spring appearanceを呈する．大腸には10～50％の症例で憩室や便秘および宿便性潰瘍などがみられ，X線ではハウストラの減少・消失が認められる．また，強皮症と原発性胆汁性肝硬変との関連性が示唆されている．

参考文献

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