胃と腸38巻5号

2003年04月発行

今月の主題 胃型早期胃癌の病理学的特徴と臨床像―分化型癌を中心に

主題

胃型の高分化型早期胃癌の病理学的特徴

著者： 渡辺玄¹ 渡辺英伸¹ 味岡洋一¹ 白下英史¹ 西倉健¹

所属機関： ¹新潟大学大学院医歯学総合研究科遺伝子制御講座分子・診断病理学分野

ページ範囲：P.693 - P.700

文献概要

要旨　高分化型早期胃癌60例に対して，CD10，MUC2，MUC5AC，HGM，MUC6の粘液染色を行い，癌の粘液形質別頻度・粘液形質変化を検討した．陽性細胞数が5％未満を陰性とすると，胃型25％，胃腸型35％，小腸型40％であった．小腸型は，CD10陽性なら，同細胞の多寡に関係なく小腸型と定義したが，この中には胃型粘液を有するものが63％存在した．胃型形質癌の全例が5％未満のMUC2陽性細胞を有していた．胃型形質癌がMUC2陽性の腸型癌へ，さらにCD10陽性の小腸型癌へ進展する経路が推定された．

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