胃と腸40巻7号

2005年06月発行

今月の主題 胃癌化学療法の進歩と課題

主題

進行胃癌（遠隔転移例）の化学療法―新規抗癌剤の可能性を含めて

著者： 安井博史¹ 朴成和¹

所属機関： ¹静岡県立静岡がんセンター消化器内科

ページ範囲：P.1015 - P.1022

文献概要

要旨　切除不能進行胃癌に対する化学療法は，best supportive careとの比較試験によって生存期間の延長が証明されてきた．しかし，化学療法間の比較でも世界的に多くの比較試験が行われてきたが，現時点で国際的にコンセンサスの得られた標準的治療は存在せず，様々な5-FU based chemotherapyにより治療されているのが現状である．最近，irinotecan，経口のフッ化ピリミジン，taxaneさらにmolecular target agents等の高い抗腫瘍効果を示す新規抗癌剤が次々に開発され，これらは単剤または併用療法での第I相，第II相試験によりそれらの有効性が示されてきている．現在，わが国において4つの第III相比較試験が行われているが，これらの新規抗癌剤によりさらなる生存期間の延長と標準治療の確立が望まれる．

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