胃と腸42巻11号

2007年10月発行

今月の主題 ESD時代における未分化型混在早期胃癌の取り扱い

主題

未分化型混在早期胃癌の病理学的特徴と問題点―分子病理学的特徴

著者： 馬場正道¹ 杉原洋行² 九嶋亮治³ 服部隆則²

所属機関： ¹済生会滋賀県病院病理科 ²滋賀医科大学病理学講座分子診断病理部門 ³滋賀医科大学附属病院病理部

ページ範囲：P.1589 - P.1596

文献概要

要旨　胃型形質をもつ分化型腺癌は未分化型へ脱分化することが知られている．このことから混在癌は分化型に由来すると考えられてきたが，E-cadherin/catenin complexの変化，p53の遺伝子異常，CGHによる系譜解析の結果からみると，混在癌には分化型に由来するもの以外に未分化型に由来するものもあることがわかった．この両者は粘膜内に印環細胞へ分化する層構造がみられるかどうかによって識別できる可能性がある．混在癌の治療方針を策定する際にも，この由来の違いを考慮することが必要である．

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