胃と腸42巻3号

2007年03月発行

今月の主題 大腸鋸歯状病変の発育進展と診断・取り扱い 序説

大腸鋸歯状病変―歴史的流れと現状の問題点

著者： 樋渡信夫¹ 岩渕正広²

所属機関： ¹いわき市立総合磐城共立病院 ²国立病院機構仙台医療センター消化器科

ページ範囲：P.251 - P.252

歴史的流れ

　鋸歯状腺腫とは，1990年にLongacreとFenoglio-Preiser¹⁾によって命名された serrated adenoma（SA）の和訳であり，過形成性ポリープに類似した鋸歯状腺管構造をもち，かつ腺腫に類似した細胞異型をもつことを特徴としている．

参考文献

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7) 岩渕正広，樋渡信夫，増田高行，他．大腸鋸歯状腺腫の診断―特に歴史的流れと現状での特性．消化器内視鏡 12 : 1077-1085, 2000

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14) Park SJ, Rashid A, Lee JH, et al. Frequent CpG island methylation in serrated adenomas of the colorectum. Am J Pathol 162 : 815-822, 2003

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16) Biemer-Huttmann A-E, Walsh MD, McGuckin MA, et al. Immunohistochemical staining patterns of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum. J Histochem Cytochem 47 : 1039-1047, 1999

17) Kambara T, Simms LA, Whitehall VLJ, et al. BRAF mutation is assocuated with DNA methylation in serrated polyps and cancers of the colorectum. Gut 53 : 1137-1144, 2004

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