胃と腸42巻6号

2007年05月発行

今月の主題 Helicobacter pyloriと胃癌 主題

Helicobacter pyloriと胃癌―背景胃粘膜の立場から―いわゆる皺襞肥大型胃炎

著者： 篠村恭久¹

所属機関： ¹札幌医科大学内科学第一講座

ページ範囲：P.953 - P.958

要旨　胃体部の皺襞肥大は胃X線検査や内視鏡検査時にしばしば観察される．その大多数は，Helicobacter pylori（H. pylori）感染に起因する胃体部粘膜の炎症細胞浸潤と腺窩の過形成，低酸症を特徴とする皺襞肥大型胃炎である．H. pyloriの除菌によりこれらの所見の改善と皺襞幅の正常化がみられる．胃癌，特に胃体部の未分化型早期胃癌のリスクは皺襞幅の増加に伴って上昇することから，皺襞肥大型胃炎はH. pylori感染者の中で危険因子であることが示唆される．皺襞肥大型胃炎においてH. pyloriの除菌が胃癌の予防に有効かどうかを今後明らかにする必要がある．

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