胃と腸43巻5号

2008年04月発行

今月の主題 linitis plastica型胃癌―病態と診断・治療の最前線

主題研究

スキルス（linitis plastica型）胃癌における癌細胞の特性，治療に向けた将来展望

著者： 平川弘聖¹ 八代正和¹

所属機関： ¹大阪市立大学大学院腫瘍外科

ページ範囲：P.833 - P.844

文献概要

要旨　スキルス胃癌は，増殖・浸潤が急速広範で根治手術不能例が多い．胃癌全体の治療成績は向上しているが，スキルス胃癌の5年生存率は10％程度と依然不良である．スキルス胃癌は，癌細胞と線維芽細胞が互いに産生する因子を介して増殖・浸潤促進作用を発現している．すなわちスキルス胃癌細胞は，同所性である胃線維芽細胞が産生するKGFにより増殖促進を受け，また，TGF-βやHGFにより浸潤促進を受けている．スキルス胃癌細胞に強く発現するチロシンキナーゼ型増殖因子レセプターFGF-R2はKGFをリガンドとし，癌-間質細胞相互作用に関与している．このFGF-R2を分子標的とした治療がスキルス胃癌に有用であることが示唆される．

参考文献

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