胃と腸43巻7号

2008年06月発行

今月の主題 消化管follicular lymphoma―診断と治療戦略 序説

消化管follicular lymphoma

著者： 平田一郎¹

所属機関： ¹藤田保健衛生大学消化管内科

ページ範囲：P.1017 - P.1018

消化管follicular lymphoma発見率の増加

　消化管悪性リンパ腫の多くはB細胞性である．消化管B細胞性リンパ腫の中で頻度の高いものはびまん性大細胞型B細胞性リンパ腫（diffuse large B-cell lymphoma；DLBCL）とMALT（mucosa-associated lymphoid tissue）リンパ腫である．一方，マントル細胞リンパ腫（mantle cell lymphoma）や濾胞性リンパ腫（follicular lymphoma）は原則的に節性のリンパ腫であり，消化管原発のものはまれと考えられてきた．ちなみに消化管のfollicular lymphomaは，女性に多く，十二指腸から小腸にかけて好発するとされている¹⁾．

参考文献

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5) Johnson PW, Rohatiner AZ, Whelan JS, et al. Patterns of survival in patients with recurrent folicular lymphoma:a 20-year study from a single center. J Clin Oncol 13:140-147, 1995

6) Czuczman MS, Grillo-Lopez AJ, White CA, et al. Treatment of patients with low-grade B-cell lymphoma with the combination of chimeric anti-CD20 monoclonal antibody and CHOP chemotherapy. J Clin Oncol 17:268-276, 1999

7) Marcus R, Imrie K, Belch A, et al. CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma. Blood 105:1417-1423, 2005

8) Forstpointner R, Dreyling M, Repp R, et al. The addition of rituximab to a combination of fludarabine, cyclophosphamide, mitoxantrone(FCM)significantly increases the response rate and prolongs survival as compared with FCM alone in patients with relapsed and refractory follicular and mantle cell lymphomas:results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood 104:3064-3071, 2004