胃と腸45巻10号

2010年09月発行

今月の主題 Crohn病小腸病変に対する診断と治療の進歩 主題

Crohn病小腸病変に対する治療効果―栄養療法の粘膜治癒効果

著者： 山本隆行¹

所属機関： ¹四日市社会保険病院IBDセンター

ページ範囲：P.1621 - P.1629

要旨　Crohn病の治療において，免疫調整剤やインフリキシマブに粘膜の炎症を消失させる効果，いわゆる粘膜治癒効果があることが最近報告されている．経腸栄養療法は，本邦ではCrohn病患者に対する第1選択の治療法として提唱されているが，その粘膜治癒効果についてはこれまで十分な評価はなされていなかった．筆者らは，活動期および寛解期のCrohn病患者を対象に臨床試験を行い，経腸栄養療法の臨床的および内視鏡的有効性を検証した．その結果，経腸栄養療法が活動期，寛解期いずれのCrohn病患者においても，臨床的にも内視鏡的にも活動性を抑制することが証明された．

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