胃と腸46巻3号

2011年03月発行

今月の主題 免疫不全状態における消化管病変

主題症例

消化管Kaposi肉腫を合併したHIV感染症の2例

著者： 小川栄一¹ 村田昌之¹ 池崎裕昭¹ 居原毅¹ 高山耕治¹ 豊田一弘¹ 貝沼茂三郎¹ 澤山泰典¹ 古庄憲浩¹ 江㟢幹宏² 松本主之² 後藤綾子³ 山元英崇³ 林純¹

所属機関： ¹九州大学病院総合診療科 ²九州大学大学院病態機能内科学 ³九州大学大学院医学研究院形態機能病理学

ページ範囲：P.303 - P.309

文献概要

要旨　HIV感染者は，日和見腫瘍として悪性腫瘍を発症しやすい．その中でもKaposi肉腫が多く，その病因はhuman herpesvirus-8感染である．〔症例1〕は23歳男性で，十二指腸から上部空腸にKaposi肉腫が認められた．病変は肺にも拡がっており，HAART（highly active antiretroviral therapy）と抗癌剤（pegylated liposomal doxorubicin）を併用したが，肺病変の進行により，入院5か月後に死亡した．〔症例2〕は35歳男性で，食道～上行結腸にかけて広範囲にKaposi肉腫が認められた．HAART単独で改善し，1年後の内視鏡検査で病変は消失した．消化管Kaposi肉腫は赤紫色調の粘膜下腫瘤であり，比較的特徴的な内視鏡像を示す．

参考文献

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