胃と腸47巻11号

2012年10月発行

今月の主題 Helicobacter pylori除菌後の胃癌

主題研究

Helicobacter pylori除菌によって何が変わるのか?―除菌後長期経過の胃粘膜萎縮（腸上皮化生を含む）の変化

著者： 村上和成¹ 兒玉雅明¹ 中川善文¹ 水上一弘¹ 沖本忠義¹ 藤岡利生¹

所属機関： ¹大分大学医学部消化器内科

ページ範囲：P.1657 - P.1662

文献概要

要旨　萎縮および腸上皮化生は，胃癌の発生母地としても重要な疾患である．本研究ではH. pylori除菌後10年間の長期にわたる経時的な組織学的な変化を検討した．除菌成功群のうち30例は，H. pylori除菌治療後10年にわたり1年おきに5点生検による経時的な経過観察を行った．萎縮，腸上皮化生の程度をUpdated Sydney Systemに従って比較検討した．萎縮は5点すべてにおいて有意な低下を認めたが，前庭部小彎は6年で有意な低下をみた．腸上皮化生は胃体部小彎で6年以降には有意な低下を認めた．除菌後の経時的な長期観察で萎縮，腸上皮化生の改善を認めた．以上より，胃癌リスクの高い背景粘膜の改善による胃癌予防の可能性が示唆された．

参考文献

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